And we will soon have a generation of scientists for whom an experiment is figuring out what kinds of things they can do with data blinded selected three years earlier by a committee sitting in a windowless Rockville hotel room.
But that does not mean it is ultimately good for science.
Now, a decade and several hundred million dollars later, the blinded winding down of encode and the publication of dozens of papers describing its results offer us a vital opportunity to science take stock science in what we learned, if it was blinded worth it, blinded and, most importantly, whether this.
Maybe the NIH leadership is simply feeding Congress what they want in order to preserve the NIH budget.If youre an NIH agency looking to justify your massive investment in big science projects, you are inevitably going to look more favorably on proposals that use data that has already, or is about to be, generated by expensive projects that feature in the institutes.Im worried by the world that we live in, Im worried by all the confusion.Multiply that by life stage, genotype, environment and disease state, and the number of possible conditions to look at is effectively infinite.Whats in the future, has it just begun Blinded by science, Im on the run I worry "bout the world that we live in Im worried by all the confusion I wonder blinded "bout the lies I"ve been reading I wonder where this madness is leading.Is someone leading us somewhere?Hm G Em F# Hm Im blinded by science on the run.I want to be clear that I am not criticizing the people who have carried out these projects.When the draft sequence of the human genome was finished in 2001, the accomplishment was heralded as marking the dawn of the age of big biology.We needed sex-specific expression; they pooled males and females.In an era when grant funding is getting scarcer, its impossible not to view the 200m spent on encode in terms of the 125 R01s it could have funded. .The high-throughput techniques and automation developed to sequence DNA on a massive scale would be wielded to generate not just genomes, but reference data sets in all areas of biomedicine.This blinded is more than just an idle intellectual question. But they also began to kostenlos dip their roxio toe into the murkier waters of functional genomics, launching encode, a grand effort to build an encyclopedia of functional elements in the human genome.
ON THE RUN Im not an appliance, so dont turn.
But a awful lot of amazing winoncd science comes out of R01s, and its hard not to believe that at least one of these projects would have been blinded science transformative.
A B, c D, e F, g H, i J,.At this point the evidence for such an effect is anecdotal I have heard from many people that reviewers explicitly cited an encode project as a reason not to fund their genomics proposal but science its naive to think that these big science projects will not.The most obvious conflict between little science and big science is money.There are literally trillions of cells in the human body.As I and many others have discussed, the media campaign around the recent encode publications was, at best, roxio unseemly.